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Drug Discovery Today ENews - December 2019

Editor's Choice

The Current issue of “The view from here” is concerned with The Best of 2019 The topic of this month’s newsletter from Drug Discovery Today is “The Best of 2019”. More

Prefilled Syringes

Free Research Articles to Download

CRISPR/Cas9: A powerful tool for identification of new targets and cancer treatment
16 December 2019
• CRISPR/Cas9 has been widely used for the identification of potential therapeutic targets in cancer. • Several potential targets such as CD38, CXCR2, MASTL and RBX2 have been identified using CRISPR/Cas9. • CRISPR/Cas9 is able to specifically target mutant alleles of oncogenes such as EGFR and KRAS. • CRISPR/Cas9 delivery methods need to be improved before entering into clinic.

Disruptive Technology

Current Outlook on Drug Resistance in Chronic Myeloid Leukemia (CML) and Potential Therapeutic Options
16 December 2019
• Bcr-Abl oncogene is the hallmark of chronic myeloid leukemia. • Leukemic cells can readily resist against tyrosine kinase inhibitor drugs. • Understanding molecular basis of adaptation will help to overcome drug-resistance. • Personalized approach is needed to identify the ideal drug therapy.

Parallel Trade

A new generation of antidepressants: an update of the pharmaceutical pipeline for novel and rapid-acting therapeutics in mood disorders based on glutamate/GABA neurotransmitter systems
16 December 2019
• Monoamine deficiency hypothesis cannot explain the neurobiology of mood disorders. • Amino acid neurotransmitters are central to the pathophysiology of mood disorders. • Novel glutamatergic/GABAergic compounds show promise and are in development. • These compounds may be available as approved clinical treatments in the near future. • The improved antidepressant pipeline should engender cautious optimism.


For a full list of downloads/ white papers, please visit

Industry News

Mogrify wins Innovation Award and Dr. Jane Osbourn, OBE receives Lifetime Achievement Award at Scrip Awards 2019 Mogrify platform recognized as having potential to transform future development of new medicines at prestigious awards ceremony. Mogrify Chair receives Lifetime Achievement Award for contributions to biologics discovery and development More

MedPharm, the leader in topical and transdermal drug delivery, has moved into its newly expanded facility in Durham, North Carolina The $4M expansion has tripled the facility’s footprint to approximately 25,000 sq. ft, significantly expanding capacity and supporting MedPharm’s continued commitment to the topical and transdermal market. More

Horizon Discovery partners with the Human Protein Atlas Horizon’s HAP1 cell line to be integrated in the HPA Cell Atlas program. Knockout cell models from Horizon chosen based on consistency and reproducibility demonstrated in validation studies. Agreement will expand open access resource, supporting genetic research globally More

SparingVision wins First Prize at EIT European Health Catapult competition SparingVision awarded First Prize in the Biotech category during the European EIT Health Summit held in Paris from 2 to 3 December More

LUNAC Therapeutics led project awarded £3.14 million under Innovate UK Biomedical Catalyst programme, to develop next-generation anticoagulant 18 month project in collaboration with University of Leeds and Medicines Discovery Catapult will deliver a new compound for treatment of thrombosis. Currently available anticoagulants carry high risk of bleeding More

RB confirms £200m UK investment commitment including new Science & Innovation Centre Hull, UK, 3rd December 2019 - RB plc, the leading global consumer health, hygiene and home company, today opens its state-of-the-art Science and Innovation Centre (“S&I Centre”) in Hull. More

René Medema appointed new chair of EU-LIFE Professor René Medema, Director of Research of the Netherlands Cancer Institute, has been appointed the new chair of EU-LIFE, an alliance of thirteen leading life science institutes in Europe, as of 1 January 2020. More


SMi’s 9th Annual Pharmaceutical Microbiology Conference
Dates: 20 January 2020 until 21 January 2020
Location: Copthorne Tara Hotel, London, UK
Website: http://www.pharma-microbiology.com/ddt

SMi’s 4th Annual 3D Cell Culture
Dates: 19 February 2020 until 20 February 2020
Location: Copthorne Tara Hotel, London, UK
Website: http://www.3d-cellculture.com/ddtl

SMi’s 22nd Annual Superbugs & Superdrugs Conference
Dates: 30 March 2020 until 31 March 2020
Location: Holiday Inn Kensington Forum, London, UK
Website: http://www.superbugssuperdrugs.com/ddt

For a full list of events and conferences, please visit

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