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Drug Discovery Today ENews - March 2020

Editor's Choice

The Current issue of “The view from here” is concerned with Allosterism The topic of this month’s newsletter from Drug Discovery Today is “Allosterism”. More

Drug Discovery Chemistry

Free Research Articles to Download

Emergence of allosteric drug-resistance mutations: New challenges for allosteric drug discovery
13 February 2020
Here, we review the emergence of allosteric drug-resistance mutations with an emphasis on examples covering clinically important therapeutic targets, including Breakpoint cluster region-Abelson tyrosine kinase (Bcr-Abl), Akt kinase [also called Protein Kinase B (PKB)], isocitrate dehydrogenase (IDH), MAPK/ERK kinase (MEK), and SRC homology 2 domain-containing phosphatase 2 (SHP2).
More

Prefilled Syringes East Coast

Allosteric inhibition of HIF-2a as a novel therapy for clear cell renal cell carcinoma
13 February 2020
A brief discussion of the role of HIF-2a in ccRCC and provide insight into recent advances in the discovery, development, and mode of action of HIF-2a allosteric inhibitors.
More

Making Pharmaceuticals

Quantifying the allosteric interactions within a G protein-coupled receptor heterodimer
13 February 2020
Here, a mathematicalmodel is presented that quantifies the allosteric interactions within a receptor heterodimer.
More

Biotrinity

For a full list of downloads/ white papers, please visit
http://www.drugdiscoverytoday.com/downloads/

Industry News

Medicines Discovery Catapult Nurture Next Generation Drug Discovery Researchers Medicines Discovery Catapult (MDC) have welcomed a cohort of MRC-funded PhD students as part of a training, talent and skills agenda to help develop the next generation of drug discovery researchers. More

PainTherapeutics-2020

Breast screening breakthrough to end unnecessary biopsies Harnessing photonics, European scientists have created a new mammographic imaging system that determines benign or malignant breast lesions - spelling an end for unnecessary biopsies and anguish for millions of women. More

HPAPI

Solving real-world problems with real-world data (RWD) How RWD and technology can help the life sciences industry re-invent clinical development More

Injectable drug delivery

Stress in small children separated from their parents may alter genes Experts in the emotional needs of small children say increased levels of the stress hormone cortisol in babies and small children who are separated from their parents, especially their mothers, could have a long-term genetic impact on future generations. In a commentary published by the Journal of the Royal Society of Medicine, the authors say that several studies show that small children cared for outside the home, especially in poor quality care and for 30 or more hours per week, have higher levels of cortisol than children at home. More

Lab of the Future USA

A New Era for Alderley Park as Glasshouse Opens Glasshouse, Alderley Park’s new hub for tech companies and forward thinking, innovative businesses has officially opened. More

Pharma Micro WC 2020

5 reasons to be optimistic about cancer Every nine seconds, there is a new cancer case diagnosed in the EU and it is currently the second leading cause of death following cardiovascular disease. In addition to the considerable impact on the lives of European citizens, cancer puts a huge strain on Europe’s health and social systems as well as the economy. More

iddst

The Native Antigen Company Introduces Novel Coronavirus Antigens Newly developed recombinant antigens derived specifically from 2019-nCoV for use in infectious disease research, and assay and vaccine development More

SDDS

Cancer-Causing Culprits Will Be Caught By Their DNA Fingerprints Causes of cancer are being catalogued by a huge international study revealing the genetic fingerprints of DNA-damaging processes that drive cancer development. Researchers from the Wellcome Sanger Institute, Duke-NUS Medical School Singapore, University of California San Diego School of Medicine, the Broad Institute of MIT and Harvard, and their collaborators around the world have achieved the most detailed list of these genetic fingerprints to date, providing clues as to how each cancer developed. More

EMBL Chemical Biology 2020

How astronauts will make their own drugs in space NASA’s Translational Research Institute for Space Health (TRISH) has funded innovative projects seeking to better protect astronauts' health during deep space missions of three years or more. Two of the six projects focus on ‘just-in-time’ medications, which allow drugs to be manufactured on-demand and on-board the spacecraft – a necessity given that most commercially available medicines have shelf lives of two years or less. More

 Inhalation and Respiratory Drug Delivery

Events

SMi’s 3rd Annual Pharmaceutical Microbiology East Coast
Dates: 29 April 2020 until 30 April 2020
Location: Sheraton Boston Hotel, Boston, USA
Website: http://www.microbiologyeastcoast.com/ddt
More

For a full list of events and conferences, please visit
http://www.drugdiscoverytoday.com/events/

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